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Viagra's other talents
Johns Hopkins and other researchers report what is believed to be the first direct evidence in lab animals that the erectile dysfunction drug sildenafil amplifies the effects of a heart-protective protein. (Source: Huliq Health News)<p> </p><p><b><i>MedWorm Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Viagra's other talents: to help a 'signaling' protein shield the heart from high blood pressure damage- 1/5/09bright lights, not-so-big pupils- 12/31/08why prostate cancer patients fail hormone deprivation therapy- 12/31/08johns hopkins scientists pull protein's tail to curtail cancer- 12/30/08
Johns Hopkins and other researchers report what is believed to be the first direct evidence in lab animals that the erectile dysfunction drug sildenafil amplifies the effects of a heart-protective protein. (Source: Johns Hopkins Medicine News)
Viagra may protect heart against damage, study finds
Viagra may do more than provide a boost in the bedroom. New research suggests that it may also increase the effects of a heart-protective protein. (Source: CTV Health)
Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload
Conclusions
SIL treatment applied to well-established hypertrophic cardiac disease can prevent further cardiac and myocyte dysfunction and progressive remodeling. This is associated with improved calcium cycling, and reduction of Cn and PKC activation may be important to this improvement. (Source: Journal of the American College of Cardiology)
Health fears grow as fake drugs flood into britain
They were made in China, labelled in French and then shipped to Singapore. They ended up in Liverpool and from there were sold straight into the heart of the NHS. As the criminal investigation continues into how a fake consignment of Zyprexa, an anti-psychotic treatment prescribed for schizophrenia, infiltrated Britain's healthcare system last year, evidence is mounting that sophisticated counterfeiting syndicates are increasingly targeting Britain's network of high-street chemists, hospitals and GP surgeries.Figures collated for the first time reveal that British border officials seized more than half a million counterfeit pills destined for the NHS and high-street chemists last year, an amount equal to the quantity of counterfeit drugs found in the whole of Europe in 2005. So vast is the...
Acute effects of sildenafil on flow mediated dilatation and cardiovascular autonomic nerve function in type 2 diabetic patients
Conclusions Sildenafil administered at a maximum single dose to T2DM men results in a mild increase in heart rate and decrease in BP, but it induces neither an acute improvement of FMD nor any adverse effects on orthostatic BP regulation, HRV and BRS. Copyright © 2008 John Wiley & Sons, Ltd. (Source: Diabetes/Metabolism Research and Reviews)<p> </p><p><b><i>MedWorm Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Despite sagging economy, viamedic reports solid online sales for erectile dysfunction drugs
Cialis and Viagra Post Double-Digit Increases for 2008 . (PRWeb Dec 25, 2008)
Read the full story at http://www.prweb.com/releases/2008/12/prweb1789724.htm (Source: PRWeb: Medical Pharmaceuticals)
Combination of doxazosin and sildenafil exerts an additive relaxing effect compared with each compound alone on human cavernosal and prostatic tissue
Conclusions. Sildenafil and doxazosin reduced adrenergic tone of prostatic and cavernosal smooth muscle and their combination provided a significant benefit when targeting relaxation of both tissues. These experiments provide support for further clinical evaluation of the sildenafil and doxazosin combination in ED patients with LUTS/BPH. Oger S, Behr-Roussel D, Gorny D, Lecoz O, Lebret T, Denoux Y, Faix A, Leriche A, Wayman C, Alexandre L, and Giuliano F. Combination of doxazosin and sildenafil exerts an additive relaxing effect compared with each compound alone on human cavernosal and prostatic tissue. J Sex Med **;**:**[ndash]**. (Source: The Journal of Sexual Medicine)
Beyond the abstract - evaluation of the safety and efficacy of sildenafil citrate for erectile ...
BERKELEY, CA (UroToday.com) - The etiology of multiple sclerosis (MS)-emergent erectile dysfunction (ED) is still matter of debate, since both... (Source: UroToday)
'sex chip' being developed by scientists
Scientists are developing an electronic "sex chip" that can be implanted into the brain to stimulate pleasure. (Source: Telegraph Health)
Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a no/cgmp-dependent mechanism
We examined the effect of sildenafil, an inhibitor of phosphodiesterase subtype 5, that catalyzes hydrolysis of 3?,5?-cyclic
guanosine monophosphate (cGMP), on indomethacin-induced small-intestinal ulceration in rats and investigated the mechanism
of this action, especially in relation to endogenous nitric oxide (NO). Animals without fasting were given indomethacin (10 mg/kg)
s.c. and then killed 24 h later. Indomethacin produced hemorrhagic lesions in the small intestine, accompanied by a promotion
of enterobacterial invasion and the expression of inducible NO synthase (iNOS) as well as myeloperoxidase (MPO) activity in
the mucosa. Sildenafil (3?20 mg/kg), given p.o. 30 min before indomethacin, dose-dependently reduced the severity of these
lesions, with co...<p> </p><p><b><i>MedWorm Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
The effect of sildenafil citrate on bladder outlet obstruction: a mouse model
To investigate if sildenafil citrate can inhibit the functional and structural changes of the detrusor in a murine model of bladder outlet obstruction (BOO). Phosphodiesterase type 5 (PDE-5) inhibitors have recently been used for treating urinary symptoms associated with prostatic obstruction, but it is unclear whether PDE-5 inhibition acts on the prostatic urethra or the bladder. In 18 male Balb/CAN mice, partial BOO was created and the mice allowed to survive for 6 weeks. Half of the mice (nine) were treated with oral sildenafil citrate daily (10 mg/kg) by oral lavage (BOO + V), and half (nine) were not (BOO). Six mice were used as sham-operated controls and received no sildenafil. The mice were assessed by urodynamics at baseline and after 6 weeks, with a measurement of volume at first ...
Sildenafil increases successful pregnancies after recurrent miscarriage
Intravaginal sildenafil citrate reduces natural killer (NK) cell activity and enhances the chances of successful pregnancy in women with a history of recurrent miscarriage, according to a report in the November issue of Fertility and Sterility. Reuters Health Information (Source: Medscape Ob/Gyn & Women's Health Headlines)
Revatio (sildenafil citrate) tablet, film coated [pfizer labs]
Updated Date: Dec 12, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
An open-label, randomized, flexible-dose, crossover study to assess the comparative efficacy and safety of sildenafil citrate and apomorphine hydrochloride in men with erectile dysfunction
Urol Int 2008;81:409-415 (DOI:10.1159/000167838) (Source: Urologia Internationalis : Last 20 articles)
Spontaneous ca2+ waves in rabbit corpus cavernosum: modulation by nitric oxide and cgmp
Conclusions. These results provide a new basis for understanding detumescent tone in the corpus cavernosum and its inhibition by NO. Sergeant GP, Craven M, Hollywood MA, McHale NG, and Thornbury KD. Spontaneous Ca2+ waves in rabbit corpus cavernosum: Modulation by nitric oxide and cGMP. J Sex Med **;**:**[ndash]**. (Source: The Journal of Sexual Medicine)<p> </p><p><b><i>MedWorm Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
A critical appraisal of erectile function in animal models of diabetes mellitus
The study of erectile function in diabetic animal models has revealed physiological alterations in neural, vascular, hormonal and endothelial function. The aims of this review are to further elucidate pathophysiological changes induced by diabetes mellitus and to introduce new concepts in the study of erectile dysfunction (ED) in animal models. The recognized pathophysiological mechanisms causing diabetic ED include oxidative stress and hormonal imbalance. The evolving treatments for ED include advanced glycosylated endproduct (AGE) inhibitors, phosphodiesterase type 5 inhibitors, protein kinase C (PKC) inhibitors, hormone replacement, and gene transfer techniques. Our current understanding of how these multiple pathophysiological mechanisms contribute to ED is discussed. In this review, d...
Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts.
This article provides an overview of the current laboratory and clinical evidence, as well as the cellular mechanisms by which the inhibitors of PDE3, PDE4 and PDE5 exert their beneficial effects on normal and ischemic hearts. It seems that PDE inhibitors hold great promise as clinically applicable agents that can improve cardiac performance and cell survival under critical situations, such as ischemic heart attack, cardiopulmonary bypass surgery, and heart failure.Acta Pharmacologica Sinica advance online publication, 8th December 2008; doi: 10.1038/aps.2008.1.
PMID: 19060915 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)
[pulmonary arterial hypertension related to systemic sclerosis in 2008.]
[Pulmonary arterial hypertension related to systemic sclerosis in 2008.]
J Mal Vasc. 2008 Dec 8;
Authors: Agard C, Haloun A, Hamidou MA
Systemic sclerosis-related pulmonary arterial hypertension (PAH) is a severe disease affecting about 1000 patients in France. In 2008, all scleroderma patients are screened for PAH by a yearly cardiac Doppler ultrasonography. The pathogenesis of systemic sclerosis-related PAH is poorly known but it seems that besides common arteriolar remodeling (media hypertrophy, intimal thickening, endothelial proliferation), venular lesions suggesting obstructive venous disease and inflammatory lesions may be also be involved. Prostacyclin and analogues, phosphodiesterase-5 inhibitors (sildenafil) and endothelin-1 receptor antagonists are proposed as specif...
Cardiovascular effects of phosphodiesterase type 5 inhibitors
Conclusions. PDE5 inhibitors are an exciting class of drugs with pleiotropic effects. Current or future PDE5 inhibitors are a conceptually attractive therapeutic strategy with potential clinical applications in a variety of cardiovascular conditions. Vlachopoulos C, Ioakeimidis N, Rokkas K, and Stefanadis C. Cardiovascular effects of phosphodiesterase type 5 inhibitors. J Sex Med **;**:**[ndash]**. (Source: The Journal of Sexual Medicine)
Pfizer has announced that it has withdrawn its application to switch the legal status of the 50mg tablet strength of sildenafil [viagra].
Page: 22 (Source: Inpharma Weekly)<p> </p><p><b><i>MedWorm Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Role of sildenafil in neurological disorders.
Page: 353DOI: 10.1097/WNF.0b013e31815cd94cAuthors: Farooq, Muhammad U. MD *; Naravetla, Bharath MD *; Moore, Philip W. DO +; Majid, Arshad MD, FRCP *; Gupta, Rishi MD *; Kassab, Mounzer Y. MD, MA * (Source: Clinical Neuropharmacology)
Sexuality and the menopause.
Authors: Pitkin J
Sexuality is innate within all women to a greater or lesser extent, and is affected by a number of extrinsic factors that occur in the menopausal transition. Assessing hormone status is difficult as evidence exists that sex hormones may differ between ethnic groups, and that bio-assays may be insensitive at lower testosterone levels. Data are available on the prevalence of female sexual dysfunction, but results from cross-sectional studies differ from those of longitudinal studies. The original traditional models of human sexual response have been challenged, and new models have been defined which show more complex interaction between intrinsic and extrinsic factors. Definitions of sexual dysfunction have been redefined. There are a limited number of randomized, place...
Pfizer has announced that it has withdrawn its application to switch the legal status of the 50mg tablet strength of sildenafil [viagra]
(Source: Inpharma)
Sildenafil trial of exercise performance in idiopathic pulmonary fibrosis
We are seeking people who have been diagnosed with idiopathic pulmonary fibrosis and have advanced disease. (Source: dukehealth.org: Duke Clinical Trials)
A critical appraisal of erectile function in animal models of diabetes mellitus.
Authors: Gur S, Kadowitz PJ, Hellstrom WJ
Summary The study of erectile function in diabetic animal models has revealed physiological alterations in neural, vascular, hormonal and endothelial function. The aims of this review are to further elucidate pathophysiological changes induced by diabetes mellitus and to introduce new concepts in the study of erectile dysfunction (ED) in animal models. The recognized pathophysiological mechanisms causing diabetic ED include oxidative stress and hormonal imbalance. The evolving treatments for ED include advanced glycosylated endproduct (AGE) inhibitors, phosphodiesterase type 5 inhibitors, protein kinase C (PKC) inhibitors, hormone replacement, and gene transfer techniques. Our current understanding of how these multiple pathophysiological mecha...<p> </p><p><b><i>MedWorm Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Persistent pulmonary hypertension of the newborn: therapeutical approach.
Authors: Latini G, Del Vecchio A, De Felice C, Verrotti A, Bossone E
Persistent pulmonary hypertension of the newborn (PPHN), is defined as a failure of the pulmonary vasculature to relax at birth and consequently of the normal adaptation to extra uterine life of the fetal heart/lung system, resulting in hypoxemia. This condition, occurs in about 1-2 newborns per 1000 live births and despite significant improvements in treatment it is associated with substantial infant mortality and morbidity. Over the years wider application of inhaled nitric oxide (iNO) therapy and improved ventilation strategies including surfactant, high-frequency oscillatory ventilation has led to a decrease in the need for invasive life-sustaining therapies such as extracorporeal membrane oxygenation (ECMO). Mort...
Pulmonary arterial hypertension: need to treat.
Authors: Lykouras D, Sampsonas F, Kaparianos A, Efremidis G, Karkoulias K, Tsoukalas G, Spiropoulos K
Pulmonary Arterial Hypertension (PAH) is defined by a persistent elevation in pulmonary artery pressure with normal left-sided pressures. It is characterized by increased pulmonary vascular resistance due to increased vascular tone and structural remodeling of pulmonary vessels. PAH is a quite rare condition, thus considering the rarity, subtle presentation, and diagnostic dilemma commonly posed by this disease, underdiagnosis and underreporting are probably widespread. In order to reach a diagnosis the use of echocardiography, right-heart catheterization and the six-minute walk test is essential. As far as therapy is concerned, the patient should be supported by oxygen, diuretics, ant...
Antidepressants causing sexual problems? give her viagra.
Antidepressants causing sexual problems? Give her Viagra.
J Fam Pract. 2008 Dec;57(12):793-6
Authors: Stulberg D, Ewigman B
Tell women for whom you prescribe selective and nonselective serotonin reuptake inhibitors (SRIs) to let you know if they develop sexual dysfunction. Offer sildenafil (50 mg with the option to increase to 100 mg) to premenopausal women on stable, effective doses of SRIs who experience this common-and treatable-side effect.
PMID: 19080762 [PubMed - in process] (Source: The Journal of Family Practice)
Additive antinociception between intrathecal sildenafil and morphine in the rat formalin test.
Additive Antinociception between Intrathecal Sildenafil and Morphine in the Rat Formalin Test.
J Korean Med Sci. 2008 Dec;23(6):1033-8
Authors: Yoon MH, Park KD, Lee HG, Kim WM, An TH, Kim YO, Huang LJ, Hua CJ
The possible characteristics of spinal interaction between sildenafil (phosphodiesterase 5 inhibitor) and morphine on formalin-induced nociception in rats was examined. Then the role of the opioid receptor in the effect of sildenafil was further investigated. Catheters were inserted into the intrathecal space of male Sprague-Dawley rats. For induction of pain, 50 microL of 5% formalin solution was applied to the hind-paw. Isobolographic analysis was used for the evaluation of drug interaction between sildenafil and morphine. Furthermore, naloxone was intrathecally given t...
Health canada warns consumers not to use firm dose and granite rooster or any unauthorized products promoted to enhance male sexual performance
Health Canada is warning consumers not to use Firm Dose and Granite Rooster, two products promoted to enhance male sexual performance, as these products may pose serious health risks. Firm Dose was found to contain an undeclared pharmaceutical ingredient similar to the prescription drug sildenafil, while the product Granite Rooster was found to contain an undeclared pharmaceutical ingredient similar to the prescription drug tadalafil. (Source: Government of Canada News - Health Canada)<p> </p><p><b><i>MedWorm Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Fda sends warning letter to actelion over tracleer flash card
ROCKVILLE, Md., Nov. 25, 2008-Today the Food and Drug Administration posted on its website a warning letter sent to Actelion Pharmaceuticals regarding a Sildenafil Flash Card for Tracleer (bosentan) tablets. The letter is... (Source: Drugs.com - Pharma News)
Pde5 inhibitors and pulmonary hypertension
Abstract Phosphodiesterases (PDEs) are important components in cellular signaling in many vascular beds. Although the most recognized
PDE inhibitor, sildenafil, a specific PDE5 inhibitor, is best known for its effect on the penile vascular bed resulting in
erection, it also has therapeutic effects in other vascular beds, including the coronary and pulmonary vasculature. The first
large, randomized, double-blind, placebo-controlled clinical trial using sildenafil in patients with pulmonary arterial hypertension
was reported in 2005. As a result of this and other studies, sildenafil is now used to treat idiopathic pulmonary hypertension.
Future studies are required to assess the potential use of other PDE5 antagonists and combination therapy on pulmonary hemodynamics,
functi...
Letters: sildenafil as treatment for antidepressant-induced sexual dysfunction
(Source: JAMA)
Letters: sildenafil as treatment for antidepressant-induced sexual dysfunction
(Source: JAMA)
Letters: sildenafil as treatment for antidepressant-induced sexual dysfunction--reply
(Source: JAMA)<p> </p><p><b><i>MedWorm Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Pictured: the twins who were born after their mother took viagra
Looking at twins Lewis and Ava today, you would never guess the struggle their parents endured to bring them into the world – nor the unique treatment that finally ended in a successful birth. (Source: the Mail online | Health)
Pictured: the twins who were born after their mother took viagra
Looking at twins Lewis and Ava today, you would never guess the struggle their parents endured to bring them into the world – nor the unique treatment that finally ended in a successful birth. (Source: the Mail online | Diet)
World anti-doping agency reviewing viagra's effects
The head of the World Anti-Doping Agency acknowledged that Viagra is being examined for its potential use as a performance-enhancing drug. (Source: CTV Health)
Pfizer pulls eu bid to sell non-prescription viagra
Pfizer Inc has pulled its bid to make its blockbuster impotence pill Viagra available in the European Union without a prescription, the company said on Thursday. Reuters Health Information (Source: Medscape Urology Headlines)
Type 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype.
Authors: Zhu B, Zhang L, Alexeyev M, Alvarez DF, Strada SJ, Stevens T
Type 5 phosphodiesterase (PDE5) inhibitors increase endothelial cell cGMP, and promote angiogenesis. However, not all endothelial cell phenotypes express PDE5. Indeed, whereas conduit endothelial cells express PDE5, microvascular endothelial cells do not express this enzyme, and they are rapidly angiogenic. These findings bring into question whether PDE5 activity is a critical determinant of the endothelial cell angiogenic potential. To address this question, human full length PDE5A1 was stably expressed in pulmonary microvascular endothelial cells. hPDE5A1 expression reduced the basal and atrial natriuretic peptide (ANP)-stimulated cGMP concentrations in these cells. hPDE5A1-expressing cells displayed attenuated net...<p> </p><p><b><i>MedWorm Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
[news focus] mycology: last stand for the body snatcher of the himalayas?
The caterpillar-hijacking fungus Cordyceps sinensis is touted as a natural Viagra. But overharvesting has put the peculiar parasite's back against the wall.Author: Richard Stone (Source: Science: This Week)
Pfizer denied permission to sell viagra over counter
European regulators have rebuffed plans by Pfizer, the world's largest pharmaceutical group, to offer its top-selling erectile dysfunction drug Viagra without... (Source: FT.com - Drugs and Healthcare)
Viagra stays behind eu counters
Pfizer withdraws application to sell drug without prescription after it hits opposition from government panel. (Source: Forbes.com Healthcare News)
Pfizer withdraws application to switch viagra to non-prescriptionstatus in europe
NEW YORK--(BUSINESS WIRE)--Nov 20, 2008 - Pfizer announced today that it has withdrawn its application to switch the legal status of the 50 mg tablet strength of Viagra from ˜prescription only' to ˜non-prescription' in the European Union... (Source: Drugs.com - Pharma News)
Pfizer drops application to switch viagra 50mg to non-prescription status in europe
Pfizer announced today that it has withdrawn its application to switch the legal status of the 50 mg tablet strength of Viagra from 'prescription only' to 'non-prescription' in the European Union (EU). (Source: Health News from Medical News Today)<p> </p><p><b><i>MedWorm Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Over-the-counter viagra bid ends
The makers of the anti-impotence drug Viagra have withdrawn an application for the medicine to be available without a prescription. (Source: BBC News | Health | UK Edition)
Effects of phosphodiesterase inhibitors on the contractile responses of isolated human seminal vesicle tissue to adrenergic stimulation
Conclusion. Our results demonstrate that PDE inhibitors can inhibit EFS-induced and spontaneous contractile activity of isolated human SV tissue. These findings might be of importance with regard to the pharmacological treatment of premature ejaculation.Ückert S, Bazrafshan S, Sonnenberg JE, and Kuczyk ME. Effects of phosphodiesterase inhibitors on the contractile responses of isolated human seminal vesicle tissue to adrenergic stimulation. J Sex Med **;**:**[ndash]**. (Source: The Journal of Sexual Medicine)
Viapro
The U.S. FDA warned consumers not to buy or use Viapro because it contains an unauthorised substance similar in structure to sildenafil. Sildenafil is a prescription drug used in the treatment of erectile dysfunction and should only be used under the supervision of a health care practitioner. (Source: Government of Canada News - Health Canada)
Pensioners to get free viagra
Mexico City is giving out free Viagra and other impotence drugs to men 70 and older. (Source: Scotsman.com News - Health)
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